A spectrum of CodY activities drives metabolic reorganization and virulence gene expression in Staphylococcus aureus.

@article{Waters2016ASO,
  title={A spectrum of CodY activities drives metabolic reorganization and virulence gene expression in Staphylococcus aureus.},
  author={Nicholas R. Waters and David J Samuels and Ranjan K Behera and Jonathan Livny and Kyu Y. Rhee and Marat R. Sadykov and Shaun R Brinsmade},
  journal={Molecular microbiology},
  year={2016},
  volume={101 3},
  pages={495-514}
}
The global regulator CodY controls the expression of dozens of metabolism and virulence genes in the opportunistic pathogen Staphylococcus aureus in response to the availability of isoleucine, leucine and valine (ILV), and GTP. Using RNA-Seq transcriptional profiling and partial activity variants, we reveal that S. aureus CodY activity grades metabolic and virulence gene expression as a function of ILV availability, mediating metabolic reorganization and controlling virulence factor production… CONTINUE READING
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