A specifically designed nanoconstruct associates, internalizes, traffics in cardiovascular cells, and accumulates in failing myocardium: a new strategy for heart failure diagnostics and therapeutics.

@article{RuizEsparza2016ASD,
  title={A specifically designed nanoconstruct associates, internalizes, traffics in cardiovascular cells, and accumulates in failing myocardium: a new strategy for heart failure diagnostics and therapeutics.},
  author={Guillermo U Ruiz-Esparza and Victor Segura-Ibarra and Andrea M. Cordero-Reyes and Keith A. Youker and Rita Elena Serda and Ana S Cruz-Solbes and Javier Amione-Guerra and Kenji Yokoi and Dickson K. Kirui and Francisca E Cara and Jesus Paez-Mayorga and Jose Humberto Flores-Arredondo and Carlos Enrique Guerrero-Beltr{\'a}n and Gerardo J Garc{\'i}a-Rivas and Mauro Ferrari and Elvin Blanco and Guillermo Torre-Amione},
  journal={European journal of heart failure},
  year={2016},
  volume={18 2},
  pages={169-78}
}
AIMS Ongoing inflammation and endothelial dysfunction occurs within the local microenvironment of heart failure, creating an appropriate scenario for successful use and delivery of nanovectors. This study sought to investigate whether cardiovascular cells associate, internalize, and traffic a nanoplatform called mesoporous silicon vector (MSV), and determine its intravenous accumulation in cardiac tissue in a murine model of heart failure. METHODS AND RESULTS In vitro cellular uptake and… CONTINUE READING
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