A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell-dependent murine model of allergic asthma.

@article{Price2013ASS,
  title={A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell-dependent murine model of allergic asthma.},
  author={Megan M. Price and Carole A Oskeritzian and Yves T. Falanga and Kuzhuvelil B Harikumar and Jeremy C. Allegood and Sergio E. Alvarez and Daniel Conrad and John Jack Ryan and Sheldon Milstien and Sarah Spiegel},
  journal={The Journal of allergy and clinical immunology},
  year={2013},
  volume={131 2},
  pages={501-11.e1}
}
BACKGROUND Sphingosine-1-phosphate (S1P), which is produced by 2 sphingosine kinase (SphK) isoenzymes, SphK1 and SphK2, has been implicated in IgE-mediated mast cell responses. However, studies of allergic inflammation in isotype-specific SphK knockout mice have not clarified their contribution, and the role that S1P plays in vivo in a mast cell- and IgE-dependent murine model of allergic asthma has not yet been examined. OBJECTIVE We used an isoenzyme-specific SphK1 inhibitor, SK1-I, to… CONTINUE READING

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