A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling.

  title={A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling.},
  author={Hao Ding and Xiaoli Wu and Hans Bostr{\"o}m and Injune Kim and Nicole Christine Wong and Bonny M-Y Tsoi and Meredith P O'Rourke and Gou Young Koh and Philippe Soriano and Christer Betsholtz and Thomas C. Hart and Mary L. Marazita and Leigh L. Field and Patrick P. L. Tam and Andras D Nagy},
  journal={Nature genetics},
  volume={36 10},
PDGF-C is a member of the platelet-derived growth factor (PDGF) family, which signals through PDGF receptor (PDGFR) alphaalpha and alphabeta dimers. Here we show that Pdgfc(-/-) mice die in the perinatal period owing to feeding and respiratory difficulties associated with a complete cleft of the secondary palate. This phenotype was less severe than that of Pdgfra(-/-) embryos. Pdgfc(-/-) Pdgfa(-/-) embryos developed a cleft face, subepidermal blistering, deficiency of renal cortex mesenchyme… CONTINUE READING


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