A specific peptide ligand-modified lipid nanoparticle carrier for the inhibition of tumor metastasis growth.

@article{Wang2013ASP,
  title={A specific peptide ligand-modified lipid nanoparticle carrier for the inhibition of tumor metastasis growth.},
  author={Zhaohui Wang and Yonghao Yu and Wenbing Dai and Jing-rong Cui and Hounan Wu and Lan Yuan and Hua Zhang and Xueqing Wang and Jiancheng Wang and Xuan Zhang and Qiang Zhang},
  journal={Biomaterials},
  year={2013},
  volume={34 3},
  pages={756-64}
}
Tumor metastasis accounts for 90% of cancer-associated deaths and is almost inaccessible by chemotherapy, surgical operation or radiotherapy. Here, a tumor metastasis-specific nanocarrier system has been constructed by modification of stealth lipid nanoparticles with a specific peptide ligand. Highly metastatic breast cancer MDA-MB-231 that stably expressed luciferase (MDA-MB-231/Luc) was used as tumor cell model. The nanocarrier was very specific for highly metastatic cancer cells in vitro and… CONTINUE READING
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