A specific orally active inhibitor of angiotensin-converting enzyme in man.

@article{Ferguson1977ASO,
  title={A specific orally active inhibitor of angiotensin-converting enzyme in man.},
  author={Roger K. Ferguson and G. A. Turini and Hans Rudolf Brunner and Haralambos Gavras and DORIS N. MCKINSTRY},
  journal={Lancet},
  year={1977},
  volume={1 8015},
  pages={775-8}
}
An orally active inhibitor of the angiotensin-converting enzyme, SQ 14,225 (D-2-methyl-3-mercaptopropanoly-L-proline), was administered to fourteen normal male volunteers to evaluate its safety and efficacy in inhibiting pressor responses to exogenous angiotensin I. SQ 14,225 produced significant blockade within 15 min of oral administration. The magnitude and duration of inhibition were dose-related. After a dose of 20 mg, complete blockade was observed for more than 2 h and partial inhibition… CONTINUE READING