A specific mutation in the promoter region of the silent cel cluster accounts for the appearance of lactose-utilizing Lactococcus lactis MG1363.

@article{Solopova2012ASM,
  title={A specific mutation in the promoter region of the silent cel cluster accounts for the appearance of lactose-utilizing Lactococcus lactis MG1363.},
  author={Ana Solopova and Herwig Bachmann and Bas Teusink and Jan Kok and Ana Rute Neves and Oscar P. Kuipers},
  journal={Applied and environmental microbiology},
  year={2012},
  volume={78 16},
  pages={5612-21}
}
The Lactococcus lactis laboratory strain MG1363 has been described to be unable to utilize lactose. However, in a rich medium supplemented with lactose as the sole carbon source, it starts to grow after prolonged incubation periods. Transcriptome analyses showed that L. lactis MG1363 Lac(+) cells expressed celB, encoding a putative cellobiose-specific phosphotransferase system (PTS) IIC component, which is normally silent in MG1363 Lac(-) cells. Nucleotide sequence analysis of the cel cluster… CONTINUE READING
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