A specific mRNA binding factor regulates the iron-dependent stability of cytoplasmic transferrin receptor mRNA.

@article{Mllner1989ASM,
  title={A specific mRNA binding factor regulates the iron-dependent stability of cytoplasmic transferrin receptor mRNA.},
  author={Ernst W. M{\"u}llner and Barbara Neupert and Lukas C. K{\"u}hn},
  journal={Cell},
  year={1989},
  volume={58 2},
  pages={373-82}
}
Iron regulates human transferrin receptor (hTR) expression by modulating the stability of cytoplasmic hTR mRNA. This regulation requires a distinct secondary structure in the mRNA 3' untranslated region. We identified a specific cytoplasmic factor that binds simultaneously to four homologous palindromes within the regulatory domain. Iron chelator induced the RNA binding activity 25-fold in parallel with mRNA. Upon the addition of iron salts, a rapid decay of factor activity closely preceded hTR… CONTINUE READING