A specific limbic circuit underlies opiate withdrawal memories.

  title={A specific limbic circuit underlies opiate withdrawal memories.},
  author={François Frenois and Luis Stinus and Francesco Di Blasi and Martine Cador and Catherine Le Moine},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={25 6},
Compulsive drug-seeking behavior and its renewal in former drug addicts is promoted by several situations, among which reactivation of drug withdrawal memories plays a crucial role. A neural hypothesis is that such memories reactivate the circuits involved in withdrawal itself and promote a motivational state leading to drug seeking or taking. To test this hypothesis, we have analyzed the neural circuits and cell populations recruited when opiate-dependent rats are reexposed to stimuli… CONTINUE READING
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