A specific laboratory test for the diagnosis of melancholia. Standardization, validation, and clinical utility.

@article{Carroll1981ASL,
  title={A specific laboratory test for the diagnosis of melancholia. Standardization, validation, and clinical utility.},
  author={Bernard J. Carroll and Michael Feinberg and John F. Greden and Janet S. Tarika and A. Ariav Albala and Roger F. Haskett and Norman Mcl. James and Ziad Kronfol and Naomi E. Lohr and Michael Lancaster Steiner and J P de Vigne and Elizabeth C. Young},
  journal={Archives of general psychiatry},
  year={1981},
  volume={38 1},
  pages={
          15-22
        }
}
Four hundred thirty-eight subjects underwent an overnight dexamethasone suppression test (DST) to standardize the test for the diagnosis of melancholia (endogenous depression). Abnormal plasma cortisol concentrations within 24 hours after dexamethasone administration occurred almost exclusively in melancholic patients. The best plasma cortisol criterion concentration, above which a DST result may be considered abnormal, was 5 microgram/dL. The optimal dose of dexamethasone was 1 rather than 2… CONTINUE READING
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