A specific inhibitor of the ran1+ protein kinase regulates entry into meiosis in Schizosaccharomyces pombe

@article{McLeod1988ASI,
  title={A specific inhibitor of the ran1+ protein kinase regulates entry into meiosis in Schizosaccharomyces pombe},
  author={Maureen V McLeod and David S. Beach},
  journal={Nature},
  year={1988},
  volume={332},
  pages={509-514}
}
In fission yeast, meiosis is initiated by transcriptional activation of the mei3+ gene, under the combined influence of the four mating-type genes. The product of the mei3+ gene acts as a critical meiotic inducer by binding non-covalently to a newly identified protein kinase encoded by the ran1+ gene and inhibiting its enzymatic activity. Inactivation of the ran1+ protein kinase is both necessary and sufficient to divert a vegetative cell from mitotic division to meiotic differentiation. 

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