A specific inhibitor of plasminogen activator inhibitor-1 suppresses rat autoimmune myocarditis.


OBJECTIVE Myocarditis is a serious disease, however no effective treatment exists. Plasminogen activator inhibitor-1 (PAI-1) is critical in cell recruitment and inflammation. Although inflammation is an essential pathological feature of acute myocarditis, the effects of PAI-1 inhibition on the development of acute myocarditis have not been well studied… (More)
DOI: 10.1517/14728222.12.11.1313