A specific induction of interleukin-10 by the Map41 recombinant PPE antigen of Mycobacterium avium subsp. paratuberculosis.

@article{Nagata2010ASI,
  title={A specific induction of interleukin-10 by the Map41 recombinant PPE antigen of Mycobacterium avium subsp. paratuberculosis.},
  author={Reiko Nagata and Satoko Kawaji and Yuu Minakawa and Xuebo Wang and Tadashi Yanaka and Yasuyuki Mori},
  journal={Veterinary immunology and immunopathology},
  year={2010},
  volume={135 1-2},
  pages={71-8}
}
Interleukin-10 (IL-10) is not only an essential immunoregulator in host immunity, but also it accounts for the intracellular survival of mycobacteria because of its inhibitory activity against anti-mycobacterial functions of macrophage. It has been also indicated that blood cells from calves infected with Mycobacterium avium subsp. paratuberculosis (Map) produce a large amount of IL-10 after stimulation with Map antigen, and it leads to suppression of Interferon-gamma (IFN-gamma) production in… CONTINUE READING