A specific growth hormone-binding protein in human plasma: initial characterization.

@article{Baumann1986ASG,
  title={A specific growth hormone-binding protein in human plasma: initial characterization.},
  author={Gerhard Baumann and Mark W Stolar and K D Amburn and C P Barsano and Bert deVries},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1986},
  volume={62 1},
  pages={134-41}
}
Human (h) GH in plasma exists as a series of size isomers, which are in part explained by the presence of hGH oligomers. However, certain aspects of circulating large mol wt hGH, such as its high relative proportion compared to that in the pituitary, are poorly understood. To explore whether binding of hGH to plasma protein(s) could contribute to the phenomenon of large mol wt hGH, we incubated freshly prepared monomeric [125I]hGH or biosynthesized [3H]hGH with normal human plasma or serum at… CONTINUE READING

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