A specific enzyme-linked immunosorbent assay for measuring beta-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease.

@article{Xia2009ASE,
  title={A specific enzyme-linked immunosorbent assay for measuring beta-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease.},
  author={Weiming Xia and Ting Yang and Ganesh M. Shankar and Imelda M. Smith and Yong Shen and Dominic M Walsh and Dennis J Selkoe},
  journal={Archives of neurology},
  year={2009},
  volume={66 2},
  pages={190-9}
}
OBJECTIVE To examine in vivo levels of beta-amyloid (Abeta) oligomers (oAbeta) vs monomeric Abeta in plasma and brain tissue of patients with sporadic and familial Alzheimer disease (AD) using a new enzyme-linked immunosorbent assay (ELISA) specific for oAbeta. DESIGN To establish the oAbeta ELISA, the same N-terminal Abeta antibody was used for antigen capture and detection. Plasma and postmortem brain tissue from patients with AD and control subjects were systematically analyzed by… CONTINUE READING