A specific enzymatic high-performance liquid chromatography method to determine N-methyl-D-aspartic acid in biological tissues.

@article{DAniello2002ASE,
  title={A specific enzymatic high-performance liquid chromatography method to determine N-methyl-D-aspartic acid in biological tissues.},
  author={Antimo D'Aniello and Antonella De Simone and Patrizia Spinelli and Salvatore D'Aniello and Margherita Branno and Francesco Aniello and Jeannette Rios and Mara Tsesarskaja and George H. Fisher},
  journal={Analytical biochemistry},
  year={2002},
  volume={308 1},
  pages={42-51}
}
Recently we demonstrated that N-methyl-D-aspartic acid (NMDA) is present as an endogenous compound in the nervous tissues and endocrine glands of the rat where it plays a role in the regulation of the luteinizing hormone, growth hormone, and prolactin (FASEB J. 14 (2000) 699; Endocrinology 141 (2000) 3861). Based on the prediction that NMDA could have future importance in neuroendocrinology, we have devised an improved method for the specific and routine determination of NMDA in biological… CONTINUE READING

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