A specific endoplasmic reticulum export signal drives transport of stem cell factor (Kitl) to the cell surface.

@article{Paulhe2004ASE,
  title={A specific endoplasmic reticulum export signal drives transport of stem cell factor (Kitl) to the cell surface.},
  author={Fr{\'e}d{\'e}rique Paulhe and Beat Albert Imhof and Bernhard Wehrle-Haller},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 53},
  pages={55545-55}
}
Stem cell factor, also known as Kit ligand (Kitl), belongs to the family of dimeric transmembrane growth factors. Efficient cell surface presentation of Kitl is essential for the migration, proliferation, and survival of melanocytes, germ cells, hemopoietic stem cells, and mastocytes. Here we demonstrate that intracellular transport of Kitl to the cell surface is driven by a motif in the cytoplasmic tail that acts independently of the previously described basolateral sorting signal. Transport… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

Similar Papers

Loading similar papers…