A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa

@article{Lu2013ASA,
  title={A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa},
  author={Genmin Lu and Francis R Deguzman and Stanley J. Hollenbach and Mark J Karbarz and Keith Abe and Gail Lee and Peng Luan and Athiwat Hutchaleelaha and Mayuko Inagaki and Pamela B Conley and David R. Phillips and Uma Sinha},
  journal={Nature Medicine},
  year={2013},
  volume={19},
  pages={446-451}
}
Inhibitors of coagulation factor Xa (fXa) have emerged as a new class of antithrombotics but lack effective antidotes for patients experiencing serious bleeding. We designed and expressed a modified form of fXa as an antidote for fXa inhibitors. This recombinant protein (r-Antidote, PRT064445) is catalytically inactive and lacks the membrane-binding γ-carboxyglutamic acid domain of native fXa but retains the ability of native fXa to bind direct fXa inhibitors as well as low molecular weight… CONTINUE READING
Highly Influential
This paper has highly influenced 11 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 24 times over the past 90 days. VIEW TWEETS
234 Extracted Citations
40 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 234 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 40 references

Evaluation of prothrombin complex concentrate and recombinant activated factor VII to reverse rivaroxaban in a rabbit model

  • A Godier
  • Anesthesiology 116,
  • 2012

Development of a recombinant antithrombin variant as a potent antidote to fondaparinux and other heparin derivatives

  • Bianchini, E.P
  • Blood 117,
  • 2011

a randomized, placebo-controlled, crossover study in healthy subjects

  • Eerenberg, E. S. et al. Reversal of rivaroxaban, dabigatran by prothrombin complex concentrate
  • Circulation 124, 1573–1579
  • 2011

a review of the literature

  • E. M. Bershad, Suarez, J. I. Prothrombin complex concentrates for oral antic hemorrhage
  • Neurocrit. Care 12, 403–413
  • 2010

Similar Papers

Loading similar papers…