A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa

  title={A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa},
  author={Genmin Lu and Francis R Deguzman and Stanley J. Hollenbach and Mark J Karbarz and Keith Abe and Gail Lee and Peng Luan and Athiwat Hutchaleelaha and Mayuko Inagaki and Pamela B Conley and David R. Phillips and Uma Sinha},
  journal={Nature Medicine},
Inhibitors of coagulation factor Xa (fXa) have emerged as a new class of antithrombotics but lack effective antidotes for patients experiencing serious bleeding. We designed and expressed a modified form of fXa as an antidote for fXa inhibitors. This recombinant protein (r-Antidote, PRT064445) is catalytically inactive and lacks the membrane-binding γ-carboxyglutamic acid domain of native fXa but retains the ability of native fXa to bind direct fXa inhibitors as well as low molecular weight… CONTINUE READING
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