A specific antidote for dabigatran: functional and structural characterization.

@article{Schiele2013ASA,
  title={A specific antidote for dabigatran: functional and structural characterization.},
  author={Felix Schiele and Joanne van Ryn and Keith A Canada and Corey Newsome and Eliud Sepulveda and John Jung Park and Herbert Nar and Tobias Litzenburger},
  journal={Blood},
  year={2013},
  volume={121 18},
  pages={3554-62}
}
Dabigatran etexilate is a direct thrombin inhibitor and used widely as an anticoagulant for the prevention of stroke in patients with atrial fibrillation. However, anticoagulation therapy can be associated with an increased risk of bleeding. Here, we present data on the identification, humanization, and in vitro pharmacology of an antidote for dabigatran (aDabi-Fab). The X-ray crystal structure of dabigatran in complex with the antidote reveals many structural similarities of dabigatran… CONTINUE READING