A specific antagonist of the p110delta catalytic component of phosphatidylinositol 3'-kinase, IC486068, enhances radiation-induced tumor vascular destruction.

@article{Geng2004ASA,
  title={A specific antagonist of the p110delta catalytic component of phosphatidylinositol 3'-kinase, IC486068, enhances radiation-induced tumor vascular destruction.},
  author={Ling Geng and Jiahuai Tan and Eric A Himmelfarb and Aaron J. Schueneman and Ken J Niermann and Jeffrey P. Brousal and Allie Fu and Kyle C. Cuneo and Edward A. Kesicki and Jennifer Treiberg and Joel S. Hayflick and Dennis E. Hallahan},
  journal={Cancer research},
  year={2004},
  volume={64 14},
  pages={4893-9}
}
The phosphatidylinositol 3'-kinase (PI3k)/protein kinase B (PKB/Akt) signal transduction pathway plays a critical role in mediating endothelial cell survival and function during oxidative stress. The role of the PI3k/Akt signaling pathway in promoting cell viability was studied in vascular endothelial cells treated with ionizing radiation. Western blot analysis showed that Akt was rapidly phosphorylated in response to radiation in primary culture endothelial cells (human umbilical vascular… CONTINUE READING

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