A specific CD36-dependent signaling pathway is required for platelet activation by oxidized low-density lipoprotein.


Platelet hyperactivity associated with hyperlipidemia may contribute to development of a prothrombotic state. We previously showed that oxidized low-density lipoprotein (oxLDL) formed in the setting of hyperlipidemia and atherosclerosis activated platelets in a CD36-dependent manner. We now show that mitogen-activated protein kinase c-Jun N-terminal kinase… (More)
DOI: 10.1161/CIRCRESAHA.108.172064


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