A species of small antisense RNA in posttranscriptional gene silencing in plants.

@article{Hamilton1999ASO,
  title={A species of small antisense RNA in posttranscriptional gene silencing in plants.},
  author={Andrew Hamilton and David C. Baulcombe},
  journal={Science},
  year={1999},
  volume={286 5441},
  pages={
          950-2
        }
}
Posttranscriptional gene silencing (PTGS) is a nucleotide sequence-specific defense mechanism that can target both cellular and viral mRNAs. Here, three types of transgene-induced PTGS and one example of virus-induced PTGS were analyzed in plants. In each case, antisense RNA complementary to the targeted mRNA was detected. These RNA molecules were of a uniform length, estimated at 25 nucleotides, and their accumulation required either transgene sense transcription or RNA virus replication. Thus… 

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