A specialized NMDA receptor function in layer 5 recurrent microcircuitry of the adult rat prefrontal cortex.

@article{Wang2008ASN,
  title={A specialized NMDA receptor function in layer 5 recurrent microcircuitry of the adult rat prefrontal cortex.},
  author={Huaixing Wang and George G Stradtman and Xiao-Jing Wang and Wen-Jun Gao},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 43},
  pages={16791-6}
}
In the prefrontal cortex, NMDA receptors are important for normal prefrontal functions such as working memory, and their dysfunction plays a key role in the pathological processes of psychiatric disorders such as schizophrenia. Little is known, however, about the synaptic properties of NMDA receptors in the local circuits of recurrent excitation, a leading candidate mechanism underlying working memory. We investigated the NMDA receptor-mediated currents at monosynaptic connections between pairs… CONTINUE READING
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Synaptic Theory of Working Memory

  • CM Hempel
  • Science
  • 2008

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