A spatial physiological model for p53 intracellular dynamics.

  title={A spatial physiological model for p53 intracellular dynamics.},
  author={Luna Dimitrio and Jean Clairambault and Roberto Natalini},
  journal={Journal of theoretical biology},
In this paper we design and analyse a physiologically based model representing the accumulation of protein p53 in the nucleus after triggering of ATM by DNA damage. The p53 protein is known to have a central role in the response of the cell to cytotoxic or radiotoxic insults resulting in DNA damage. A reasonable requirement for a model describing intracellular signalling pathways is taking into account the basic feature of eukaryotic cells: the distinction between nucleus and cytoplasm. Our aim… CONTINUE READING