A spatial model of tumor-host interaction: application of chemotherapy.

@article{Hinow2009ASM,
  title={A spatial model of tumor-host interaction: application of chemotherapy.},
  author={P. Hinow and P. Gerlee and L. Mccawley and V. Quaranta and Madalina Ciobanu and S. Wang and Jason M. Graham and Bruce P. Ayati and J. Claridge and K. Swanson and M. Loveless and A. Anderson},
  journal={Mathematical biosciences and engineering : MBE},
  year={2009},
  volume={6 3},
  pages={
          521-46
        }
}
  • P. Hinow, P. Gerlee, +9 authors A. Anderson
  • Published 2009
  • Biology, Medicine
  • Mathematical biosciences and engineering : MBE
  • In this paper we consider chemotherapy in a spatial model of tumor growth. The model, which is of reaction-diffusion type, takes into account the complex interactions between the tumor and surrounding stromal cells by including densities of endothelial cells and the extra-cellular matrix. When no treatment is applied the model reproduces the typical dynamics of early tumor growth. The initially avascular tumor reaches a diffusion limited size of the order of millimeters and initiates… CONTINUE READING
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