A spatial model for integrin clustering as a result of feedback between integrin activation and integrin binding.

@article{Welf2012ASM,
  title={A spatial model for integrin clustering as a result of feedback between integrin activation and integrin binding.},
  author={Erik S. Welf and Ulhas P. Naik and Babatunde A. Ogunnaike},
  journal={Biophysical journal},
  year={2012},
  volume={103 6},
  pages={1379-89}
}
Integrins are transmembrane adhesion receptors that bind extracellular matrix (ECM) proteins and signal bidirectionally to regulate cell adhesion and migration. In many cell types, integrins cluster at cell-ECM contacts to create the foundation for adhesion complexes that transfer force between the cell and the ECM. Even though the temporal and spatial regulation of these integrin clusters is essential for cell migration, how cells regulate their formation is currently unknown. It has been… CONTINUE READING
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