A spatial gradient coordinates cell size and mitotic entry in fission yeast

@article{Moseley2009ASG,
  title={A spatial gradient coordinates cell size and mitotic entry in fission yeast},
  author={James B. Moseley and Adeline Mayeux and Anne Paoletti and Paul Nurse},
  journal={Nature},
  year={2009},
  volume={459},
  pages={857-860}
}
Many eukaryotic cell types undergo size-dependent cell cycle transitions controlled by the ubiquitous cyclin-dependent kinase Cdk1 (refs 1–4). The proteins that control Cdk1 activity are well described but their links with mechanisms monitoring cell size remain elusive. In the fission yeast Schizosaccharomyces pombe, cells enter mitosis and divide at a defined and reproducible size owing to the regulated activity of Cdk1 (refs 2, 3). Here we show that the cell polarity protein kinase Pom1… 
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TLDR
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TLDR
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TLDR
This study shows how cell growth progressively inhibits fission yeast Wee1 through dynamic bursts of localization to cortical node structures that contain Wee1 inhibitory kinases.
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References

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Fission yeast Pom1p kinase activity is cell cycle regulated and essential for cellular symmetry during growth and division
TLDR
It is shown that Pom1p kinase activity is cell cycle regulated in correlation with the state of cellular symmetry: the activity is high during symmetrical growth and division, but lower when cells grow at just one end, and there may be related roles of homologous protein kinases ubiquitously present in all eukaryotes.
The Elm1 Kinase Functions in a Mitotic Signaling Network in Budding Yeast
TLDR
A model in which the Elm1 kinase functions in a mitotic signaling network that controls events required for normal bud growth and cytokinesis is proposed, while the Swe1 kinases functions in an checkpoint pathway that delays nuclear division in response to defects in these events.
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TLDR
Results show that nim1/cdr1 functions as a positive regulator of mitosis by directly phosphorylating and inactivating the mitotic inhibitor Weel.
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TLDR
It is described that a synthetic lethal genetic screen has identified cdr2(+), a gene that has an important role in the mitotic control and is consistent with a model in which Cdr2 negatively regulates Wee1.
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TLDR
Observations show that Nim1 promotes the onset of mitosis by inhibiting Wee1, and Wee1 is hyperphosphorylated in cells that overproduce Nim1.
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TLDR
A gene, pom1, is identified that provides positional information for both growth and division in S. pombe and may position the growth and cytokinesis machineries by interaction with both the actin and microtubule cytoskeletons.
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TLDR
It is reported here that in a pom1 polarity mutant, which displays a monopolar growth pattern, Mid1p distribution expands towards the non-growing cell tip, uncoupling Mid 1p localization from nuclear position, which accounts for the displacement of the contractile ring during mitosis.
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TLDR
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