A spatial gradient coordinates cell size and mitotic entry in fission yeast

  title={A spatial gradient coordinates cell size and mitotic entry in fission yeast},
  author={J. Moseley and A. Mayeux and A. Paoletti and P. Nurse},
  • J. Moseley, A. Mayeux, +1 author P. Nurse
  • Published 2009
  • Biology, Medicine
  • Nature
  • Many eukaryotic cell types undergo size-dependent cell cycle transitions controlled by the ubiquitous cyclin-dependent kinase Cdk1 (refs 1–4). The proteins that control Cdk1 activity are well described but their links with mechanisms monitoring cell size remain elusive. In the fission yeast Schizosaccharomyces pombe, cells enter mitosis and divide at a defined and reproducible size owing to the regulated activity of Cdk1 (refs 2, 3). Here we show that the cell polarity protein kinase Pom1… CONTINUE READING
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