A source for the special catalytic power of enzymes: orbital steering.


The velocities of acid catalyzed esterification and gamma-lactonizations were studied to test the sensitivity of a chemical reaction to the orientation of the reacting atoms. Variation in orientation of the attacking oxygen atom relative to the carbon atom of the carboxylic acid was achieved by using bicyclic ring systems to limit the conformational… (More)


3 Figures and Tables

Slides referencing similar topics