A sorting nexin PpAtg24 regulates vacuolar membrane dynamics during pexophagy via binding to phosphatidylinositol-3-phosphate.

@article{Ano2004ASN,
  title={A sorting nexin PpAtg24 regulates vacuolar membrane dynamics during pexophagy via binding to phosphatidylinositol-3-phosphate.},
  author={Yoshitaka Ano and Takeshi Hattori and Masahide Oku and Hiroyuki Mukaiyama and Masaharu Baba and Yoshinori Ohsumi and Yasuyoshi Sakai},
  journal={Molecular biology of the cell},
  year={2004},
  volume={16 2},
  pages={
          446-57
        }
}
Diverse cellular processes such as autophagic protein degradation require phosphoinositide signaling in eukaryotic cells. In the methylotrophic yeast Pichia pastoris, peroxisomes can be selectively degraded via two types of pexophagic pathways, macropexophagy and micropexophagy. Both involve membrane fusion events at the vacuolar surface that are characterized by internalization of the boundary domain of the fusion complex, indicating that fusion occurs at the vertex. Here, we show that PpAtg24… CONTINUE READING

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Pexophagy :

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Pexophagy: autophagic degradation of peroxisomes.

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Pexophagy: The Selective Degradation of Peroxisomes

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Turnover of organelles by autophagy in yeast.

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