A sonic hedgehog signaling domain in the arterial adventitia supports resident Sca1+ smooth muscle progenitor cells.

Abstract

We characterize a sonic hedgehog (Shh) signaling domain restricted to the adventitial layer of artery wall that supports resident Sca1-positive vascular progenitor cells (AdvSca1). Using patched-1 (Ptc1(lacZ)) and patched-2 (Ptc2(lacZ)) reporter mice, adventitial Shh signaling activity was first detected at embryonic day (E) 15.5, reached the highest levels… (More)
DOI: 10.1073/pnas.0711382105

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@article{Passman2008ASH, title={A sonic hedgehog signaling domain in the arterial adventitia supports resident Sca1+ smooth muscle progenitor cells.}, author={Jenna N Passman and Xiu Rong Dong and San-pin Wu and Colin T. Maguire and Kelly A. Hogan and Victoria L Bautch and Mark W. Majesky}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2008}, volume={105 27}, pages={9349-54} }