A somatostatin analogue, octreotide, inhibits the occurrence of second primary tumors and lung metastasis after resection of hepatocellular carcinoma in mice.

@article{Jia2009ASA,
  title={A somatostatin analogue, octreotide, inhibits the occurrence of second primary tumors and lung metastasis after resection of hepatocellular carcinoma in mice.},
  author={Wei-dong Jia and Ge-liang Xu and Wei Wang and Zhi-Hua Wang and Jian-sheng Li and Jin-liang Ma and Wei-hua Ren and Yong-sheng Ge and Ji-hai Yu and Wenbin Liu},
  journal={The Tohoku journal of experimental medicine},
  year={2009},
  volume={218 2},
  pages={155-60}
}
Occurrence of second primary tumors and metastasis remains the major obstacles to prolonged survival of patients with primary hepatocellular carcinoma (HCC). A somatostatin analogue, octreotide, has been previously reported to inhibit the growth of human HCC xenografts in nude mice through its anti-angiogenic activity. It is therefore important to investigate whether octreotide could prevent second primary hepatomas or distant metastasis following resection of primary HCC. In this study, nude… CONTINUE READING