A solution to the subdiffusion-efficiency paradox: Inactive states enhance reaction efficiency at subdiffusion conditions in living cells

  title={A solution to the subdiffusion-efficiency paradox: Inactive states enhance reaction efficiency at subdiffusion conditions in living cells},
  author={Leila Esmaeili Sereshki and Michael A. Lomholt and Ralf Metzler},
  journal={EPL (Europhysics Letters)},
Macromolecular crowding in living biological cells effects subdiffusion of larger biomolecules such as proteins and enzymes. Mimicking this subdiffusion in terms of random walks on a critical percolation cluster, we here present a case study of EcoRV restriction enzymes involved in vital cellular defence. We show that due to its so far elusive propensity to an inactive state the enzyme avoids non-specific binding and remains well-distributed in the bulk cytoplasm of the cell. Despite the… 

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行 わ れ た 1段審査 を尊重 して 配分 した. 審査 の 印象 と して は次 の 点 が 挙げ られ る. 1) ボ ー ダ ー ラ イ ン で は 1段審査 員 の コ メ ン トが 必要で あ るが,それ に 欠 け る もの が 多 い. 2) 申請書 の 書 き方 と して ,2 段審査 委員 は も ち ろん ,点数をっ け る 1段 審査員 で も,決して 自分の 分野の 専

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