A solution to the rheumatoid factor paradox: pathologic rheumatoid factors can be tolerized by competition with natural rheumatoid factors.

@article{Stewart1997AST,
  title={A solution to the rheumatoid factor paradox: pathologic rheumatoid factors can be tolerized by competition with natural rheumatoid factors.},
  author={Jeffrey J. Stewart and H Agosto and Samuel Litwin and J Darlene Welsh and Mark A Shlomchik and Martin Weigert and Philip E. Seiden},
  journal={Journal of immunology},
  year={1997},
  volume={159 4},
  pages={1728-38}
}
Rheumatoid factors (RF) associated with arthritic joint erosion are only seen transiently, if at all, in nondiseased individuals. Therefore, a tolerance mechanism must exist that prevents pathologic RF B cells from expressing Abs. Surprisingly, it has been shown that pathologic RF B cells are not tolerized by any previously established tolerance mechanism… CONTINUE READING