A soluble phospholipase of Toxoplasma gondii associated with host cell penetration.

@article{Saffer1991ASP,
  title={A soluble phospholipase of Toxoplasma gondii associated with host cell penetration.},
  author={L D Saffer and Joseph D. Schwartzman},
  journal={The Journal of protozoology},
  year={1991},
  volume={38 5},
  pages={454-60}
}
We previously reported that phospholipase increases host cell penetration by Toxoplasma gondii. Here we show that calcium-dependent phospholipase A (PLA) activity is found in the supernatant of sonically disrupted T. gondii. When fractions of disrupted T. gondii were incubated with host cells, the release of fatty acids and lysolipids was detected. Fractions of sonically disrupted T. gondii with PLA activity increased T. gondii host cell penetration in a bioassay. In addition, a protein of… CONTINUE READING

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