A soluble insulin-like growth factor I receptor that induces apoptosis of tumor cells in vivo and inhibits tumorigenesis.

@article{DAmbrosio1996ASI,
  title={A soluble insulin-like growth factor I receptor that induces apoptosis of tumor cells in vivo and inhibits tumorigenesis.},
  author={Chiara D'Ambrosio and Andr{\'e}s Ferber and Mariana Resnicoff and Renato Baserga},
  journal={Cancer research},
  year={1996},
  volume={56 17},
  pages={4013-20}
}
By a frame-shift mutation, we have engineered a human IGF-I receptor (IGF-IR) cDNA that produces a receptor 486 amino acids long (plus the 30 amino acids of the signal peptide). This receptor, which we have designated as 486/STOP, is partially secreted into the medium of cells in culture and markedly inhibits the autophosphorylation of the endogenous IGF-IRs as well as the activation of the signaling pathway. The 486/STOP receptor acts as a strong dominant negative for several growth functions… CONTINUE READING

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Insulin - likegrowthfactorI ( IGFI ) andtheIGFI receptor prevent etoposideinduced apoptosis

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