A soluble form of the pilus protein FimA targets the VDAC-hexokinase complex at mitochondria to suppress host cell apoptosis.

@article{Sukumaran2010ASF,
  title={A soluble form of the pilus protein FimA targets the VDAC-hexokinase complex at mitochondria to suppress host cell apoptosis.},
  author={Sunil K Sukumaran and Nai Yang Fu and Chua Boon Tin and Kah Fei Wan and San San Lee and Victor Chun Kong Yu},
  journal={Molecular cell},
  year={2010},
  volume={37 6},
  pages={768-83}
}
Inhibition of apoptotic response of host cells during an early phase of infection is a strategy used by many enteroinvasive bacterial pathogens to enhance their survival. Here, we report the identification of a soluble form of the pilus protein FimA from the culture supernatants of E. coli K1, Salmonella, and Shigella that can potently inhibit Bax-mediated release of cytochrome c from isolated mitochondria. Similar to the infected cells, HCT116 cells stably expressing FimA display a delay in… CONTINUE READING
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