A soluble form of alpha1,3-galactosyltransferase functions within cells to galactosylate glycoproteins.

@article{Cho1997ASF,
  title={A soluble form of alpha1,3-galactosyltransferase functions within cells to galactosylate glycoproteins.},
  author={Steve K Cho and Richard D. Cummings},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 21},
  pages={13622-8}
}
It has been assumed that membrane-bound glycosyltransferases function within the Golgi apparatus to glycosylate glycoproteins. We now report, however, that a truncated, soluble recombinant form of the murine alpha1,3-galactosyltransferase expressed in human 293 cells is highly efficient and comparable to the full-length enzyme in alpha-galactosylating both newly synthesized membrane-associated and secreted glycoproteins. Although the soluble enzyme was secreted by cells as expected, we also… CONTINUE READING

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