A soluble form of IL-27Rα is a natural IL-27 antagonist.

  title={A soluble form of IL-27Rα is a natural IL-27 antagonist.},
  author={C{\'e}line Dietrich and Sophie Candon and Frank M. Ruemmele and Odile Devergne},
  journal={Journal of immunology},
  volume={192 11},
IL-27 is a cytokine of the IL-12 family that plays a key role in the regulation of inflammatory and T cell responses. Its receptor is composed of IL-27Rα and gp130 and activates the STAT pathway. We show in this study, using an ELISA that we developed, that a naturally occurring soluble form of IL-27Rα (sIL-27Rα) is produced by human activated CD4(+) and CD8(+) T cells, B cells, myeloid cells, and various cell lines. sIL-27Rα is present at a mean concentration of 10,344 ± 1,274 pg/ml in the… CONTINUE READING

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