A soluble divalent class I MHC/IgG1 fusion protein activates CD8+ T cells in vivo.

@article{Carey2005ASD,
  title={A soluble divalent class I MHC/IgG1 fusion protein activates CD8+ T cells in vivo.},
  author={Brenna C. Carey and M Delay and Jane E. Strasser and Claudia L Chalk and Kristen L Dudley-McClain and Gregg N. Milligan and Hermine I Brunner and Sherry Thornton and Raphael Hirsch},
  journal={Clinical immunology},
  year={2005},
  volume={116 1},
  pages={65-76}
}
CD8+ T lymphocytes recognize tumor and viral antigens bound to class I major histocompatibility complexes (MHC). Tumors and viruses may evade detection by preventing antigen presentation. The present study was designed to determine whether a soluble divalent fusion protein, containing the extracellular domains of a class I MHC molecule fused to beta2-microglobulin and the constant domains of IgG1, could induce an immune response in vivo. Administration to mice of the fusion protein loaded with… CONTINUE READING