A soluble and immunoreactive fragment of pemphigus foliaceus antigen released by trypsinization of viable human epidermis.

@article{Martins1990ASA,
  title={A soluble and immunoreactive fragment of pemphigus foliaceus antigen released by trypsinization of viable human epidermis.},
  author={Ciro R Martins and R. S. Labib and Evandro Ararigb{\'o}ia Rivitti and Luis A Diaz},
  journal={The Journal of investigative dermatology},
  year={1990},
  volume={95 2},
  pages={208-12}
}
Pemphigus foliaceus (PF) antigen is a transmembrane desmosomal glycoprotein (desmoglein I), part of which is located on the keratinocyte surface. Previous studies have shown that after trypsinization of viable human epidermis, this antigen is no longer detected on the surface of detached keratinocytes. It was not known, however, if this loss of antigenic activity was due to destruction, internalization, or cleavage of the antigen itself. In the present study we investigated the fate of the PF… CONTINUE READING