A solid-phase approach to the phallotoxins: total synthesis of [Ala7]-phalloidin.

@article{Anderson2005ASA,
  title={A solid-phase approach to the phallotoxins: total synthesis of [Ala7]-phalloidin.},
  author={Marc O Anderson and Anang A. Shelat and R. Kiplin Guy},
  journal={The Journal of organic chemistry},
  year={2005},
  volume={70 12},
  pages={4578-84}
}
Herein we report a solid-phase synthetic approach to [Ala7]-phalloidin (1). Prior syntheses of phallotoxins were carried out using solution-phase routes that required large scale and preclude library production. The route presented here consists of solution-phase preparation of key orthogonally protected amino acid building blocks, followed by a solid-phase peptide synthesis sequence, featuring two resin-bound macro-cyclization reactions. The final product mixture was composed of two… CONTINUE READING

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