A sodium channel defect in hyperkalemic periodic paralysis: potassium-induced failure of inactivation.

@article{Cannon1991ASC,
  title={A sodium channel defect in hyperkalemic periodic paralysis: potassium-induced failure of inactivation.},
  author={Stephen C Cannon and R. H. Brown and David P. Corey},
  journal={Neuron},
  year={1991},
  volume={6 4},
  pages={619-26}
}
Hyperkalemic periodic analysis (HPP) is an autosomal dominant disorder characterized by episodic weakness lasting minutes to days in association with a mild elevation in serum K+. In vitro measurements of whole-cell currents in HPP muscle have demonstrated a persistent, tetrodotoxin-sensitive Na+ current, and we have recently shown by linkage analysis that the Na+ channel alpha subunit gene may contain the HPP mutation. In this study, we have made patch-clamp recordings from cultured HPP… CONTINUE READING
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