A smart platform for hyperthermia application in cancer treatment: cobalt-doped ferrite nanoparticles mineralized in human ferritin cages.

@article{Fantechi2014ASP,
  title={A smart platform for hyperthermia application in cancer treatment: cobalt-doped ferrite nanoparticles mineralized in human ferritin cages.},
  author={Elvira Fantechi and Claudia Innocenti and Matteo Zanardelli and Maria Fittipaldi and Elisabetta Falvo and M T Dom{\'e}nech Carb{\'o} and Valbona Shullani and Lorenzo Di Cesare Mannelli and Carla Ghelardini and Anna Maria Ferretti and Alessandro Ponti and Claudio Sangregorio and Pierpaolo Ceci},
  journal={ACS nano},
  year={2014},
  volume={8 5},
  pages={4705-19}
}
Magnetic nanoparticles, MNPs, mineralized within a human ferritin protein cage, HFt, can represent an appealing platform to realize smart therapeutic agents for cancer treatment by drug delivery and magnetic fluid hyperthermia, MFH. However, the constraint imposed by the inner diameter of the protein shell (ca. 8 nm) prevents its use as heat mediator in MFH when the MNPs comprise pure iron oxide. In this contribution, we demonstrate how this limitation can be overcome through the controlled… CONTINUE READING
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