A small sample confidence interval approach to assess individual bioequivalence.

@article{Hyslop2000ASS,
  title={A small sample confidence interval approach to assess individual bioequivalence.},
  author={Terry Hyslop and Francis Hsuan and Daniel J. Holder},
  journal={Statistics in medicine},
  year={2000},
  volume={19 20},
  pages={2885-97}
}
The concept of interchangeable pharmaceutical products has been examined in great detail in the literature. Anderson and Hauck proposed a statistical random coefficient model to study 'switchability', and coined the phrase 'individual bioequivalence' which they defined with a probability-based inequality. Since that paper there has been considerable work and discussion. The Food and Drug Administration has recommended the introduction of individual bioequivalence (IBE) and population… CONTINUE READING