A small peptide sequence is sufficient for initiating kinesin-1 activation through part of TPR region of KLC1.

@article{Kawano2012ASP,
  title={A small peptide sequence is sufficient for initiating kinesin-1 activation through part of TPR region of KLC1.},
  author={Takanori Kawano and Masahiko Araseki and Yoichi Araki and Masataka Kinjo and Tohru Yamamoto and Toshiharu Suzuki},
  journal={Traffic},
  year={2012},
  volume={13 6},
  pages={834-48}
}
Kinesin-1 anterogradely transports vesicles containing cargo proteins when a protein-protein interaction activates it from an inhibited state. The C-terminal cytoplasmic region of kinesin-1 cargo protein Alcadeinα (Alcα) interacts with the KLC1 subunit's tetratricopeptide repeat (TPR) region, activating kinesin-1's association with vesicles and anterograde transport. We found that either of two 10-amino-acid WD motifs in Alcα cytoplasmic region was necessary and sufficient to initiate this… CONTINUE READING
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