A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen

@article{Warbrick1995ASP,
  title={A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen},
  author={E. Warbrick and D. Lane and D. Glover and L. Cox},
  journal={Current Biology},
  year={1995},
  volume={5},
  pages={275-282}
}
BACKGROUND p21WAF1 is a potent inhibitor of the cell-cycle regulatory cyclin-dependent kinases (Cdks). It acts on Cdks in the G1 and S phases of the cell cycle, and also binds to proliferating cell nuclear antigen (PCNA), blocking DNA replication in vitro. Transcription of p21WAF1 can be induced by the human tumour suppressor protein p53, suggesting that the action of p21WAF1 may be important in cancer prevention. We have investigated the interaction between p21WAF1 and PCNA using a genetic two… Expand
Structural and biochemical studies of human proliferating cell nuclear antigen complexes provide a rationale for cyclin association and inhibitor design.
Inhibition of Nucleotide Excision Repair by the Cyclin-dependent Kinase Inhibitor p21 (*)
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References

SHOWING 1-10 OF 59 REFERENCES
Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme.
Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair
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1
2
3
4
5
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