A small nucleolar RNA requirement for site-specific ribose methylation of rRNA in Xenopus.

@article{Tycowski1996ASN,
  title={A small nucleolar RNA requirement for site-specific ribose methylation of rRNA in Xenopus.},
  author={Kazimierz T. Tycowski and Carissa Smith and M. F. Shu and Joan A Steitz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 25},
  pages={
          14480-5
        }
}
Vertebrate cells contain a large number of small nucleolar RNA (snoRNA) species, the vast majority of which bind fibrillarin. Most of the fibrillarin-associated snoRNAs can form 10- to 21-nt duplexes with rRNA and are thought to guide 2'-O-methylation of selected nucleotides in rRNA. These include mammalian UHG (U22 host gene)-encoded U25-U31 snoRNAs. We have characterized two novel human snoRNA species, U62 and U63, which similarly exhibit 15- (with one interruption) and 12-nt… CONTINUE READING
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