A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells.

@article{Wu2002ASM,
  title={A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells.},
  author={Xu Wu and Sheng Ding and Qiang Ding and Nathanael S Gray and Peter G. Schultz},
  journal={Journal of the American Chemical Society},
  year={2002},
  volume={124 49},
  pages={14520-1}
}
Purmorphamine, which is a 2,6,9-trisubstituted purine compound, was discovered through cell-based high-throughput screening from a heterocycle combinatorial library. It differentiates multipotent mesenchymal progenitor cells into an osteoblast lineage. It will serve as a unique chemical tool to study the molecular mechanisms of osteogenesis of stem cells and bone development. 

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