A small molecule that blocks fat synthesis by inhibiting the activation of SREBP.

@article{Kamisuki2009ASM,
  title={A small molecule that blocks fat synthesis by inhibiting the activation of SREBP.},
  author={Shinji Kamisuki and Q. Mao and Lutfi Abu-Elheiga and Ziwei Gu and Akira Kugimiya and Youngjoo Kwon and Tokuyuki Shinohara and Yoshinori Kawazoe and Shin-ichi Sato and Koko Asakura and H Y Choo and Juro Sakai and Salih J. Wakil and Motonari Uesugi},
  journal={Chemistry & biology},
  year={2009},
  volume={16 8},
  pages={882-92}
}
Sterol regulatory element binding proteins (SREBPs) are transcription factors that activate transcription of the genes involved in cholesterol and fatty acid biosynthesis. In the present study, we show that a small synthetic molecule we previously discovered to block adipogenesis is an inhibitor of the SREBP activation. The diarylthiazole derivative, now called fatostatin, impairs the activation process of SREBPs, thereby decreasing the transcription of lipogenic genes in cells. Our analysis… CONTINUE READING