A small-molecule targeting the microRNA binding domain of argonaute 2 improves the retinoic acid differentiation response of the acute promyelocytic leukemia cell line NB4.

Abstract

Argonaute proteins are pivotal regulators of gene expression mediating miRNAs function. Modulating their activity would be extremely useful to elucidate the processes governing small-RNAs-guided gene silencing. We report the identification of a chemical compound able to compete with Argonaute 2 miRNAs binding, and we demonstrate that this functional… (More)
DOI: 10.1021/cb500286b

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@article{Masciarelli2014AST, title={A small-molecule targeting the microRNA binding domain of argonaute 2 improves the retinoic acid differentiation response of the acute promyelocytic leukemia cell line NB4.}, author={Silvia Masciarelli and Roberto Quaranta and Ilaria Iosue and Gianni Colotti and Fabrizio Padula and Greta Varchi and Francesco Fazi and Alberto Del Rio}, journal={ACS chemical biology}, year={2014}, volume={9 8}, pages={1674-9} }